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Alterations in the expression of mucin genes, production of the mucin, and dehydration of the mucus layer are main pathogenesis in patients with COPD

However, long-term use of very high doses (exceeding 5 mg per day) may pose certain risks, such as masking the early hematological signs of vitamin B12 deficiency, thereby potentially delaying the diagnosis of its neurological complications ( In brief, folic acid may play a beneficial role in ameliorating core pathological features of PCOS, including IR and chronic low-grade inflammation, likely mediated via its anti-inflammatory, antioxidant, and lipid metabolism-regulating properties

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Vriend J, Reiter RJ