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sc-98884) was from Santa Cruz Bio (Dallas, TX, USA)

Buhrman JS

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In addition, the thiolester may directly combat the ability of fentanyl to suppress the central processes driving expiration under fentanyl-induced hypoxic/hypercapnic conditions and/or the direct inhibitory effects of fentanyl on expiratory muscle activity 11,12,13,14,15 , although it should be noted that there is evidence that opioids can actually increase expiratory muscle activity under certain circumstances 135

For inclusion in the Extension Phase studies, subjects must have completed the Main Phase with FBG 150 mg/dL