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Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome

Patients require lifelong hydroxocobalamin injections, typically 1mg every three months following an initial loading regimen (or every two months if there was neurological involvement)

The GSH:GSSG ratio serves as a sensitive marker of cellular oxidative status, with healthy cells maintaining ratios exceeding 100:1

Myeku et al., 2012)