This alcohol-induced steatosis is further compounded by the systemic insulin resistance from obesity, which independently drives an influx of FFA to the liver
Acute Gallbladder Disease In a pool of Study 1 and 2, cholelithiasis was reported in 1.1% of ZEPBOUND-treated patients and 1% of placebo-treated patients, cholecystitis was reported in 0.7% of ZEPBOUND-treated patients and 0.2% of placebo-treated patients, and cholecystectomy was reported in 0.2% of ZEPBOUND-treated patients and no placebo-treated patients
Mechanistically, GLP-1 agonists enhance insulin secretion after meals, slow gastric emptying, and suppress glucagon releaseall of which contribute to better glycemic control and weight management
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60 MohsenzadehS.EsmaeiliM.MoosaviF.ShahrtashM.SaffariB.MohabatkarH