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Serotonin Serotonin is synthesized through a two-step process involving a tetrahydrobiopterin-dependent hydroxylation reaction (catalyzed by tryptophan-5-monooxygenase, also called tryptophan hydroxylase) and then a decarboxylation catalyzed by DOPA decarboxylase (also known as aromatic L-amino acid decarboxylase)

doi: 10.1038/357605a0 106 LaurellCBErikssonS

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doi: 10.1681/ASN.2008050497 155 SchreiberAPhamCTHuYSchneiderWLuftFCKettritzR