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The lack of RANKL gene expression in mouse osteoblasts causes a significant reduction in mature osteoclasts (Nakashima et al., 2011

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It is recognized as the key to destroying fatty acid hydroperoxides ( Ferrozois, a new form of regulation of cell death, is primarily attributed to cellular lipid peroxidation (LPO) due to insufficient or absent GPX4 activity, ultimately causing cell death ( 2 O 2 ) to water (Figure 4)