According to the SUSTAIN 6 trial, the average increase in heart rate is between 2.75-3.2 beats per minute (bpm), which is clinically insignificant. While the average heart rate increase is between two and three beats per minute, some individuals have experienced an increase of up to 10 bpm in resting heart rate after administering a 1.5 mg dose of semaglutide
However, weight loss (caused by Ozempic or otherwise) can influence these hormones
(Ozempic, approved for Type 2 diabetes, and Wegovy, approved for weight loss, both contain the same drug, called semaglutide.) Tchang said that while earlier clinical trials for drugs like semaglutide for diabetes and weight loss found that the drugs also improved blood pressure and cholesterol two risk factors for heart disease the Food and Drug Administration needs standalone studies looking at heart health in order for a company to be able to say the drug has that benefit
Here is how it does this [4]: It starts with Semaglutide activating GLP-1 receptors This augments insulin secretion, causing the correct release of insulin Inhibits glucagon release Suppresses hepatic gluconeogenesis All of this takes place rather rapidly and the body adjusts by keeping blood glucose levels stable, slowing the release of food from the stomach, and thus the user has fewer unwanted effects of hyperglycemia
Nausea, headache, fatigue...all cleared up within a week or 2 each time my dose was increased