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However, overlapping primary studies were predominantly concentrated in a limited number of large-scale, frequently cited RCTs in the field of GLP-1 RAs-such as LEADER, SUSTAIN, EXSCEL, HARMONY Outcomes, REWIND, ELIXA, SELECT, PIONEER, AWARD, AMPLITUDE, LEAD, SCALE, and STEP

These metabolites have been shown to exert neuroprotective effects by maintaining the integrity of the bloodbrain barrier (BBB), modulating immune responses, and promoting neuronal health (Wang et al., 2018)

[63] found that ethylene glycol-induced CaOx crystals in rats induced autophagy and upregulated the expression of BECN1

Larger trials would provide more precise effect estimates and detect smaller differences between groups