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Following acute stress, an increase in adenosine release triggers an adaptive response aimed at restoring homeostasis, mainly by activating A 1 receptors that promote an inhibitory control of neuronal hyperexcitability [54]

The authors have no competing interests as defined by Springer, or other interests that might be perceived to influence the results and/or discussion reported in this paper

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Calcineurin inhibitors exert their immunosuppressive effects by binding to the nuclear factor of activated T-cells, thereby reducing the release of cytokine interleukin-2 from T cells and T proliferation