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Therefore, glucagon-like peptide-1-receptor agonists (GLP-1 agonists) are attractive adjuvant therapy in type 1 diabetes due to their weight reduction dimension, and glycemic benefits (16)

Acknowledgements This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF- 2022M3E5E8081191 to C.-K.P.) and (NRF- 2021R1A5A2030333 to Y.H.K.), both of which are funded by the Korean government

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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

Thyroid dysfunction should be considered in patients with persistent fatigue, as it can present with lethargy, weight changes, and low mood