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Additionally, the N-terminal extension may partially shield protease-sensitive sites on the IGF-1 backbone from insulin-degrading enzyme (IDE) and other endopeptidases

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Factors affecting response time include baseline GH/IGF-1 levels, age (older people may show greater responses), training and nutrition protocols, dosing frequency and consistency, sleep quality and stress care, and personal genetic factors

responders may be identified as children with autism or ASD with lower plasma and/or intracellular levels of GSH, tGSH, or both, when compared to children without a diagnosis of autism