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In addition to traditional immune cells, in human adipocytes, pharmacological stimulation of D2 induced the expression and release of IL-6 (Wang, Villar et al., 2018), and in human keratinocytes, D2 activation increased IL-6 and IL-8 levels (Parrado et al., 2012)

Most GLP-1 agonists (semaglutide, liraglutide, dulaglutide, tirzepatide) do not require dose adjustment for mild-to-moderate renal impairment, though caution is warranted in severe renal impairment

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GSSG, glutathione disulfide