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10.1161/STROKEAHA.114.005427 Stroke 79 HelmsH

Retatrutide is a next-generation triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, making it one of the most studied compounds in modern metabolic peptide research

Large randomized trials evaluating liraglutide, semaglutide, and dulaglutide consistently demonstrate reductions in major adverse cardiovascular events, including myocardial infarction, stroke, and cardiovascular death

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However, retatrutide lacks the long-term safety data that tirzepatide has accumulated, and it is not yet FDA-approved for any indication