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In the context of mucosal inflammation, the activation of NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS) by inflammatory cytokines leads to the production of superoxide and nitric oxide by intestinal epithelial cells (IECs), neutrophils, and macrophages (66)

Acknowledgements The authors wish to thank the investigators of COPDGene for access to their considerable body of data and continued support of this research

James Glutathione Injection is a treatment that involves injecting the antioxidant compound glutathione directly into the bloodstream

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Week 12