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SKU: 71353703100
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Description

Participants self-injected themselves with placebo for 4 weeks followed by a 16-week administration of a GHRH analog

Clin Cancer Res 16:130140

doi: 10.1016/j.mam.2016.11.011

(PubMed) Clarke JD, Hsu A, Riedl K, et al

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically