Some nanomaterials are specifically engineered to be activated by enzymes that are overexpressed in pathogenic bacteria
However, this approach faces several challenges, including the potential for the blood-brain barrier (BBB) to mask or dilute CNS-specific signals and the difficulty in distinguishing brain-derived markers from those originating systemically (87,88)
Wu Y, Matsui MS, Chen JZS, et al
This chemical stimulates the production of melanin, which darkens the skin, and while it can supposedly work without UV exposure, its effects are enhanced when used alongside sun exposure or tanning sun beds
With these results in hand we became convinced that a clinically useful small molecule analog could be designed that possessed the important characteristics of metabolic stability, extended half-live, BBB penetrability and the capability to enhance cognitive functioning