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Furthermore, inactivation of key androgenic enzymes, such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase, together with decreased testosterone synthesis suggest a potential impairment of male gonadal function

In summary, individual health, drinking speed, concurrent substance use, and dietary factors work together to influence the threshold at which alcohol becomes lethal

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The GABA system is the brains main calming circuit