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Specifically, research shows that Bifidobacterium adolescentis is a high GABA producer.[ref] Lactobacillus brevis DPC6108 and Lactobacillus rhamnosus are also probiotic strains that produce GABA.[ref][ref] A 2024 double blind placebo controlled trial found that a probiotic formulation of Lactobacillus brevis and Lactiplantibacillus plantarum reduced symptoms of depression and improved mood, but did not affect stress levels

These factors highlight the need for careful consideration and monitoring when prescribing these medications, especially in individuals at risk of eating disorders (Bartel et al., 2024)

Additional research done in the decades since is also encouraging

Compounded tirzepatide is not FDA-approved and is mixed by a pharmacy from raw ingredients