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Safety endpoints included the number of treatment-emergent adverse events (AEs) and the number of hypoglycaemic episodes up to approximately 31 weeks, defined according to the three-tier ADA 2018 classification [23], and the change from baseline to week 26 in laboratory assessments and vital signs

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Because of this difference a concentration gradient amenable to flow exists and the Na+/K+ ATPase pump effects the transfer of these two ions pushing out 3 Na+ ions for every 2 K+ ions pumped back into the cell