In any case, the authors were self-aware enough to state that: In all, our preliminary observations support the need for prospective, randomized clinical trials with larger numbers of patients to investigate this approach further far from a proclamation that their study is Gospel, but rather that their entire correspondence is simply them saying: We found a potentially interesting effect in a few T1DM patients
Cold Spring Harbor Perspectives in Biology , 8 (6), a021899
The product of UA oxidation by heme-peroxidases, urate free radical, can combine with superoxide to produce the oxidant HOOU [Citation72] which decomposes mainly into hydroxyisourate and allantoin (Citation29] and identified, for the first time, the production of HOOU by isolated peripheral neutrophils [Citation26]
Do you get systemic effects from that or is it mostly topical
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