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Conclusion We have shown that oral glutathione supplement might have some beneficial effects as a skin-lightening agent, as demonstrated in certain subgroups of our cohort

The de novo synthesis of glutathione requires the consecutive action of two enzymes, -glutamylcysteine synthetase (-GCS) and GSH synthetase [13,33]

In order to investigate the mechanisms underlying APR-246 activity against AML cells, we exposed the cells treated with APR-246 to inhibitors of various cell death pathways (Figure 2A)

doi: 10.1021/jf4044056 245 WidjajaGRudiansyahMSultanMQAnsariMJIzzatSEAl JaberMSet al

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