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Monitor closely for hypothalamic amenorrhea, a condition where excessive energy deficit suppresses the hypothalamic-pituitary-gonadal axis

For context, the placebo group in the same trial lost only 2.4%, making the drug-attributable weight loss approximately 12.5 percentage points

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Laser and Energy-Based Treatments For specific, localised pigmentation concerns such as solar lentigines, freckles, and discrete hyperpigmented lesions laser treatments offer targeted, evidence-supported options: Q-switched Nd:YAG laser : Delivers short, high-energy pulses that fragment melanin deposits