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Authors contributions Study concept and design (GYW), drafting of the manuscript (EMY, GYW), literature review and writing of the manuscript (EMY), critical revision of the manuscript for important intellectual content (GYW), manuscript proofreading (GYW, EMY)

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ERP gratefully acknowledges the financial support provided by the institutional budget of the Instituto de Biotecnologa, UNAM, to his laboratory, as well as the economic incentive granted to him by the Sistema Nacional de Investigadoras e Investigadores (SNII), Mxico and Center for BioMolecular Structure (CBMS), which is primarily supported by the National Institutes of Health, National Institute of General Medical Sciences (NIGMS) through Grant #P30GM133893, and DOE Office of Biological and Environmental Research FWP #BO070