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Burneo, J

TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

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Isso especialmente relevante em tendes tecidos pouco vascularizados que tm dificuldade de regenerao pela escassez de aporte de nutrientes

Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK: Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons