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10b black) can denote a structural configuration where the ligand is effectively interacting with the active site whereas the second peak, having a higher SASA value can correspond to a structural change which allows more solvent molecules to interact with the protein
The crude S10 was used in the next step without further purification
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Most of the compounds synthesized showed good inhibitory activities, the best of which was compound 10 , which had an IC 50 value of 0.046 M (Figure 7)
Be sure to research the specific dosing recommendations for your chosen peptide and adjust accordingly
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