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Methods: Nonclinical experiments were conducted in humanised murine models and nonhuman primates (NHPs) to assess pharmacokinetics, KLKB1 editing, pharma-codynamics, and durability

Until more data is available, hypothyroid patients using semaglutide should be monitored closely, with a focus on maintaining stable thyroid function and promptly addressing any side effects or complications that arise

Why GLP-1 (semaglutide or tirzepatide) Might Be Particularly Relevant in Older Adults Cardiometabolic protection Large cardiovascular outcome trials (e.g., SELECT , SUSTAIN-6 ) show semaglutide reduces major adverse cardiovascular events (MACE), and subgroup analyses suggest these benefits extend to older patients

CS and LSM drafted the manuscript

These are soft, and I can break them into small pieces