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Key concerns include copper accumulation from elevated GHK-Cu dosing due to the fixed 5:1:1 blend ratio, pro-angiogenic activity relevant to individuals with oncologic history, and injection site irritation from subcutaneous administration.

One research team concluded that using BPC-157 may not be appropriate, particularly when undetected cancer cells might be present

Inflammatory skin diseases in dogs have been associated with oxidative stress and reduced levels of the fat-soluble antioxidant vitamin E

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There is no need for long-term, ongoing supplementation with selenium