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Treatment courses often extend for at least three to six months before meaningful cosmetic changes might be appreciated, and continued application may be required to maintain any gains

That said, results vary

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As obese subjects appear to display a more rapid gastric emptying of solids compared to normal weight subjects (86) and the natural increase in plasma GLP-1 is attenuated in obese subjects (86, 87), the smaller release of GLP in the obese subjects could cause less pronounced satiety of food intake, leading to earlier onset of the next meal