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Baseline differences and the retrospective design should be considered when interpreting these findings

When used with insulin or sulfonylureas, there is an increased risk of low blood sugar (hypoglycemia)

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But it can lead to muscle reduction if used without proper nutrition and consistent strength training

A study assessing the acute effect of liraglutide in vagotomized subjects did implicate the vagus nerve in mediating the appetite effect (188), but the sample size in the study was small and subjects had a very low appetite at baseline, making it difficult to draw conclusions