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Despite the slight increase, the overall risk remained very low at around 0.5% in every 1,000 people

Subsequently, cumulative vasorelaxation concentration-response curves were generated by challenging the pre-contracted rings with increasing concentrations of acetylcholine (10 -9 to 10 -5 M) and then after re-equilibration, to increasing concentrations of sodium nitroprusside (10 -9 to 10 -5 M)