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At 48 weeks, the least-squares mean percentage change in body weight in the retatrutide groups was -8.7% (1 mg), -17.1% (combined 4 mg), -22.8% (combined 8 mg), and an astounding -24.2% (12 mg), compared to -2.1% in the placebo group

Neurodegenerative Dementias: Clinical Features and Pathological Mechanisms