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Its effects are abrogated by pharmacological blockade of PKC or NADPH oxidase, underscoring the centrality of ROS in this pathway [55, 56]

Most congenital nevi are not sampled because they display asymmetric features but because they have changed in appearance

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Acknowledgments We would like to thank all volunteers for their participation in this study and thank laboratory staff members from Chemical Pathology Unit of Hospital Sultan Ismail Johor Bahru and Endocrine Unit of Universiti Kebangsaan Malaysia Medical Centre (UKMMC) for their cooperation and valuable assistance