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A particular translational challenge concerns the highly publicized preclinical findings on isoleucine restriction and lifespan extension (103, 104)

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103 the Bonferroni procedure is recommended for general use since it is easiest to apply, has the widest range of applications, and gives critical values that will be lower than those of other procedures if the investigator is able to limit the number of comparisons, and that will be only slightly larger than those of other procedures if many comparisons are made

Structured resistance training is the cornerstone of muscle development and can be highly effective when combined with adequate protein intake (typically 1.62.2 g/kg body weight per day for those engaged in regular strength training)