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Extended ATX supplementation, spanning a period of 8 months, led to a partial reversal of Erastin-induced alterations in human LECs from ARC models, which included the suppression of GPX4, an accumulation of ROS, and a decline in mitochondrial membrane potential (144)

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The autophagy activator rapamycin not only ameliorates fluoride-induced autophagic flux blockage by correcting autophagic degradation impairment but also inhibits fluoride-mediated ferroptosis by reducing the iron content and suppressing lipid peroxidation