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The compounds quinolinium scaffold mimics nicotinamides structure, allowing it to compete for the NNMT active site while avoiding interactions with other enzymes

Inflammation Metformin reduces chronic inflammation, mitigating inflammation-related aging processes and decreasing the risk of age-related diseases

Biomolecules 10 , 147 (2020)

It helps to reduce lipid peroxidation and restores antioxidant enzyme activity

Given that chemokine upregulation can result in chronic inflammation associated with onset and progression of age-related neurodegenerative diseases such as AD, our study employed MCP-1 staining in the frontal cortex and the hippocampus to assess the extent of possible inflammatory reactivity to amyloid plaques and microglial activity (Singh et al., 2021