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It is frequently underdiagnosed, contributing to acute heart failure, sudden death, and chronic dilated cardiomyopathy 1,2

A 2023 review in Cells described these agents as promising therapies across cardiovascular, renal, neurodegenerative, and metabolic conditions, while noting that the relative contribution of direct cellular effects versus improved cardiometabolic regulation remains under investigation [4]

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GLP-1 agonists address the insulin resistance mechanism directly, and several studies have documented period regularization in women with PCOS on GLP-1 therapy

Studies have shown that GLP-1 drugs can reduce lean mass, but the results are mixed