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Preclinical studies indicate that simultaneous or near-simultaneous administration produces maximal synergy, with synergistic effects declining as the interval between administrations exceeds 15-30 minutes

The process is responsible for the formation of urea solutes such as indoxyl sulfate, p-cresyl sulfate, phenyl sulfate, cholate, hippurate, dimethylglycine, 3-guanidino-butyrate, glutarate, 2-hydroxy-pentanoate, trimethylamine N-oxide, and phenaceturate

Benzodiazepines shift your brain's balance of GABA (the main inhibitory neurotransmitter) and can indirectly affect other brain chemicals like serotonin (which regulates blood vessels and pain)

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