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Holst, is referred to as the incretin effect. Incretins are a group of metabolic hormones, released by the GI tract, that cause a decrease in blood glucose (sugar) levels

FDA has flagged issues with compounded GLP-1 versions in the past

Jayasuriya et al., 2021)

Further supporting a cardiometabolic role of GLP-1 (9-36amide), both GLP-1 (7-36amide) and GLP-1 (9-36amide), but not exendin-4, promote vasodilation in isolated and ex vivo cultured mesenteric blood vessels [201], i.e., the vasodilatory effect of GLP-1 (7-36amide) was not different relative to that of GLP-1 (9-36amide) and was likewise preserved in GLP-1R KO mice [201]