When administered therapeutically, GLP-1 receptor agonists work through several mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [1] [4] Suppressing glucagon release from alpha cells, reducing hepatic glucose output Slowing gastric emptying , which helps moderate post-meal blood glucose rises Promoting satiety through central nervous system pathways, potentially supporting weight reduction Investigational transdermal GLP-1 delivery systems typically utilise specialised technologies such as microneedles or active delivery methods rather than conventional patches, as GLP-1 molecules are large peptides that do not easily penetrate the skin barrier

Keywords: default mode network, dmn, executive function, food noise, glp-1, glp-1 receptor agonists, mindfulness, obesity, prospection, semaglutide Introduction and background Food noise is defined as "persistent thoughts about food that are perceived by the individual as unwanted and/or dysphoric and may cause harm to the individual, including social, mental, or physical problems" [1]
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