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10.1080/08998280.2015.11929178 16 BowersL

When to contact your GP or prescriber: Injection site symptoms persisting beyond 3-4 days Concerns about injection technique or medication administration Difficulty adhering to treatment due to pain or anxiety Questions about managing minor injection site reactions Any unexpected or concerning symptoms following injection Maintaining open communication with your healthcare team ensures optimal treatment outcomes and allows prompt identification and management of any complications

However, our previous data [44] showing highly elevated serum circulating immune complexes and IgG levels in sporadic ALS patients during disease progression suggest that a humoral immune response might initiate adaptive immunity in ALS