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In agreement with this hypothesis, serotonin synthesis in both ADF and NSM is regulated by food history 80,92 , serotonin levels in ADF are increased by pathogen exposure 20 , and serotonin synthesis in NSM is induced by mitochondrial toxins 32

For example, ASCT2 facilitates the uptake of Gln into the cells, whereas LAT1 is responsible for transporting Gln out of the cell in exchange for leucine, thereby activating mTOR

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Owing to the rapid reaction between superoxide anions and NO, these so called kindling radicals would lead to the production of ONOO , followed by eNOS uncoupling and subsequent eNOS-mediated superoxide production (bonfire radical, see Figure 2)