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This can have secondary implication on the host immune system due to potential increased translocation of bacteria and their metabolites [234]

Lipid peroxidation principally involving the oxidative degradation of polyunsaturated fatty acids (PUFAs) in membrane phospholipids, in conjunction with reactive oxygen species

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The SURMOUNT-1 trial specifically noted that participants with a BMI of 35 or higher who received the 15mg tirzepatide dose lost an average of 26.5% of their body weight, substantially higher than the overall trial average