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Under conditions of chronic stress or systemic inflammation, enzymes such as indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are upregulated, diverting TRP metabolism away from 5-HT synthesis toward KYN production, with profound consequences for both peripheral physiology and central nervous system (CNS) function

Documentation should state the form and the basis of any quantity claim

2023 Apr 7;cd230023

There were conflicting findings within in vitro and in vivo studies regarding the influence of neurodegenerative-induced stress and GLP-1RAs on p62 levels

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