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Proc Natl Acad Sci U S A (1987) 84:34348

46 The metabolism of islet beta-cells is designed to be sensitive to blood glucose levels as the hexokinase isozyme found in these cells is glucokinase which has a reduced affinity for substrate, resulting in glucose catabolism occurring when glucose concentration in the blood is 5mM or higher

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We proposed to calculate the weight scalar by dividing the CY 2025 estimated aggregate weight by the unscaled CY 2026 estimated aggregate weight

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