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While exendin-4 triggered a similar degree of mitochondrial network remodelling as above in Control RNAi-treated cells, SPHKAP knockdown resulted in disrupted mitochondrial morphology at vehicle conditions, which somewhat resembled that of exendin-4-stimulated Control RNAi-treated cells in terms of tubularity but had further visual abnormalities

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HGP is decreased in Dpp4 hep/ mice but not mice with deletion of Dpp4 from Tie2 + endothelial cells via GLP-1 and GIP-dependent pathways