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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain

investigated the warm and cold types of AIHA (wAIHA and cAIHA, respectively) and demonstrated that eryptosis is predominantly driven by cold IgM and/or IgA antibodies rather than warm IgG autoantibodies, as shown by increased PS exposure in response to autoantibodies [329]