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Muscle Nerve 51 , 505513 (2015)

Multiple meta-analyzes have attempted to consolidate these findings: A systematic review found pooled IBS incidence rates of 12% among COVID-19 patients Cross-sectional studies report prevalence rates of 13% , whereas longitudinal studies show rates of 16% The subtypes distribution shows IBS-D (diarrhea-predominant) at 5% , IBS-C (constipation-predominant) at 2% , and IBS-M (mixed) at 1% The wide variation in reported figuresfrom as low as 0.17% to as high as 20%stems from differing diagnostic standards, with Rome IV criteria yielding substantially lower prevalence estimates than Rome III

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Higher levels of PCBP1, an iron chaperone protein involved in the ferritin-related iron storage pathway, suggest an increased need to bind iron which could be an indiator of iron overload in the AD-cBOs [51]