In rats, intravitreal injection of TNF- correlates with optic nerve degeneration and delayed death of retinal neuronal cells, associated with increased expression of NF-B p65 in the optic nerve, suggesting a link to TNF--induced axonal degeneration (165)
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Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)
Plaintiffs in these Ozempic cases claim that the weight loss drugs warning label was insufficient and that the drug companies failed to disclose important safety information during clinical trials
