glp 1 induced pancreatitis PSCs and GLP-1R: occurrence in normal pancreas, acute/chronic and effect of their activation by a GLP-1R agonist GLP-1 Agonists and Pancreatitis Risk

Thomas EL, Saeed N, Hajnal JV, Brynes A, Goldstone AP, Frost G, et al

Sci Rep (2016) 6:30033

Caffeines neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice

Collectively, the GLP-1-microbiota-metabolite-gut-brain-muscle network integrates metabolic, inflammatory, and neuroendocrine pathways to support skeletal muscle maintenance, enhance functional strength, and reduce sarcopenia risk, highlighting the potential of GLP-1-based and microbiota-targeted strategies in the management of aging-related and metabolic disorders

PRMT5 and AHCY enzymatic assays Each respective drug and vehicle was diluted with the assay buffer to the final concentrations indicated in the graphs