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In the brain, GLP-1 is synthesized by preproglucagon neurons, which are distributed in the nucleus of the solitary tract of the brain stem [2,3,4,5]

The Limits: What the Science Still Doesnt Support Despite the excitement, researchers are cautious: Most addiction trials are ongoing

The gap reflects both the dual-receptor mechanism of tirzepatide (GLP-1 plus GIP) and the trial populations

Collectively, these results highlight the role of vagal afferents in mediating the metabolic and appetite-regulating effects of peripheral GLP-1, thereby linking gut-derived signals to central regulatory circuits

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